SLC 1 A 5 ( solute carrier family 1 ( neutral amino acid transporter ) , member 5 )
نویسندگان
چکیده
Review on human SLC1A5, with data on DNA/RNA, on the protein encoded and pathological and physiological implications.
منابع مشابه
Cationic and neutral amino acid transporter transcript abundances are differentially expressed in the equine intestinal tract.
To test the hypothesis that AA transporter transcripts are present in the large intestine and similarly expressed along the intestinal tract, mRNA abundance of candidate AA transporter genes solute carrier (SLC) family 7, member 9 (SLC7A9), SLC7A1, SLC7A8, and SLC43A1 encoding for b(0,+)-type AA transporter (b(0,+)AT), cationic AA transporter-1 (CAT-1), L-type AA transporter-2 (LAT-2), and L-ty...
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OBJECTIVE A diverse range of lipid oxidation products detected in oxidized low-density lipoprotein (oxLDL) and atherosclerotic lesions are capable of eliciting biological responses in vascular cells. We performed DNA microarray experiments to explore novel responses of human umbilical vein endothelial cells (HUVECs) to oxLDL and its components. METHODS AND RESULTS cDNA microarray analysis sho...
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The transporters for glutamine and essential amino acids, ASCT2 (solute carrier family 1 member 5, SLC1A5) and LAT1 (solute carrier family 7 member 5, SLC7A5), respectively, are overexpressed in aggressive cancers and have been identified as cancer-promoting targets. Moreover, previous work has suggested that glutamine influx via ASCT2 triggers essential amino acids entry via the LAT1 exchanger...
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Emerging evidence indicates that lysosome function extends beyond macromolecular degradation. Genetic and functional defects in components of the lysosomal transport machinery cause lysosomal storage disorders implicating the lysosomal solute carrier (SLC) transporters as essential to vital cell processes. The pathophysiology and therapeutic potential of lysosomal SLC transporters are highlight...
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240 words Introduction: 559 words Discussion: 953 words Abbreviations: SLC, solute carrier; CNT, concentrative nucleoside transporter; ASBT, apical sodium-dependent bile acid transporter; SERT, serotonin transporter; PEPT, peptide transporter; OCTN, organic zwitterion/cation transporter; OATP, organic anion transporting polypeptide; ENT, equilibrative nucleoside transporter; IBD, inflammatory b...
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تاریخ انتشار 2014